Arrange the following steps of the cancer metastatic cascade in the correct sequential order from initiation to colonization: 1. Intravasation into blood or lymphatic vessels. 2. Local invasion of the basement membrane and extracellular matrix. 3. Extravasation into the parenchyma of distant organs. 4. Survival in the circulation and arrest in capillary beds. 5. Colonization and angiogenesis at the secondary site. Select the correct answer using the codes given below:

Options:

• A: 1-2-4-3-5
• B: 2-1-4-3-5
• C: 2-1-3-4-5
• D: 1-2-3-4-5

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