Arrange the following stages of T-lymphocyte development in the thymus in the correct chronological order from earliest to latest: 1. Migration of lymphoid progenitors from the bone marrow to the thymus. 2. Expression of both CD4 and CD8 co-receptors (Double-Positive stage). 3. Positive selection of cells that can bind self-MHC molecules. 4. Negative selection of cells that bind self-MHC with too high affinity (clonal deletion). 5. Migration of single-positive (CD4+ or CD8+) mature T-cells to secondary lymphoid organs. Select the correct sequence:

Options:

• A: 1-3-2-4-5
• B: 2-1-3-5-4
• C: 1-2-4-3-5
• D: 1-2-3-4-5

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