Why is Secretory IgA (sIgA) found in colostrum and mucosal secretions highly resistant to proteolytic degradation in the harsh environment of the infant's gastrointestinal tract?

Options:

  • A: Because it exists as a monomer with highly hydrophobic variable regions.
  • B: Due to the presence of the secretory component wrapped around the IgA dimer, which sterically hinders enzymatic cleavage.
  • C: Because it contains a high concentration of disulfide bonds in its heavy chain constant region (CH3).
  • D: Due to its association with maternal macrophages that shield it from gastric acid.

Related Practice Questions: