Consider the following statements regarding the molecular basis of Sickle Cell Anemia: 1. It is caused by a point mutation in the beta-globin gene of hemoglobin. 2. The mutation results in the substitution of glutamic acid by valine at the sixth position of the beta-globin chain. 3. Under high oxygen tension, the mutant hemoglobin undergoes polymerization, causing the red blood cells to become sickle-shaped. Which of the statements given above is/are correct?

Options:

• A: 2 and 3 only
• B: 1 and 2 only
• C: 1 and 3 only
• D: 1, 2 and 3

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