Colchicine, an alkaloid used in plant breeding and karyotype analysis, arrests cell division at which specific stage of mitosis, and what is its primary mechanism of action?

Options:

  • A: Prophase, by preventing the condensation of chromatin into chromosomes.
  • B: Metaphase, by inhibiting microtubule polymerization and preventing spindle fiber formation.
  • C: Anaphase, by preventing the enzymatic cleavage of cohesin proteins at the centromere.
  • D: Telophase, by blocking the formation of the contractile ring during cytokinesis.

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